FOXO4-DRI
Animal / in-vitro onlyFOXO4 D-retro-inverso peptide · senolytic peptide
A senolytic peptide that disrupts the FOXO4–p53 complex so senescent cells undergo apoptosis. Aged and chemotherapy-damaged mice showed restored fur density, renal function and fitness. No human data exist.
D-retro-inverso 20-mer from the FOXO4 forkhead domain (mirror-image construct)
Research compound only. No FDA/EMA approval, no registered human trials, no established human dose.
Primary sources
- Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging · Cell 2017 · Preclinical mechanistic + in vivo · Mixed ↗
- FOXO4 peptide targets myofibroblast and ameliorates bleomycin-induced pulmonary fibrosis in mice · J Cell Mol Med 2022 · Disease-model animal study · Animal ↗
- The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI · Nat Commun 2025 · Structural / in-vitro study · In vitro ↗