04 · Molecule explorer
Select a peptide. Read its sources.
Compound · 113 indexed
BPC-157
Tissue repair · Gut integrityGEPPPGKPADDAGLV
Body Protection Compound 157 · PL 14736
Proposed to promote angiogenesis and modulate nitric oxide and VEGF signalling, accelerating healing of tendon, ligament, muscle and gut tissue in animal injury models. No validated human receptor or pharmacokinetic profile has been published, and nearly all supportive data come from a small cluster of laboratories using rodent models.
- Residues
- 15
- Mass
- ≈1419 Da
- Evidence
- Animal / in-vitro only
- Sources
- 4 papers
Structure & pharmacology
- Pentadecapeptide fragment of a protective protein found in human gastric juice
- Unusually stable in gastric acid for a peptide of its size
- No confirmed receptor; proposed action through VEGF and nitric-oxide signalling
Regulatory status
Not approved by FDA or EMA. Investigated as PL 14736 for inflammatory bowel disease but never marketed. Prohibited in sport (WADA).
Primary sources
Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth
Staresinic M, et al. · Journal of Orthopaedic Research · 2003 · Controlled rodent study with in-vitro cell assay · Model: Animal ↗
PMID 14554208 ·
Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat
Cerovecki T, et al. · Journal of Orthopaedic Research · 2010 · Controlled rodent study · Model: Animal ↗
PMID 20225319 ·
Achilles detachment in rat and stable gastric pentadecapeptide BPC 157: promoted tendon-to-bone healing and opposed corticosteroid aggravation
Krivic A, et al. · Journal of Orthopaedic Research · 2006 · Controlled rodent study · Model: Animal ↗
Modulation of early functional recovery of Achilles tendon to bone unit after transection by BPC 157 and methylprednisolone
Krivic A, et al. · Inflammation Research · 2008 · Controlled rodent study · Model: Animal ↗
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